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Serious symptoms1 of sickle cell disease are emergencies and need treatment right away. Seek care or call 9-1-1 if someone with SCD is experiencing:  

  • Serious anemia can cause fatigue, shortness of breath, dizziness, and irregular heartbeat.  
  • Fever. If the person has a fever of more than 101.3 degrees Fahrenheit, or 38.5 degrees Celsius, they may have a serious infection. Seek attention from a healthcare provider and treatment with antibiotics right away. Some people need to be hospitalized for care. 
  • Chest pain, coughing, fever, and shortness of breath. These may be symptoms of acute chest syndrome which requires hospitalization. 
  • Warning signs of stroke (brain injury): sudden weakness, numbness on one side of the body, confusion, or trouble speaking, seeing, or walking. Call 9-1-1 for any of these warning signs of a stroke.  
      • F = Face drooping or twisting 
      • A = Arm weakness 
      • S = Speech difficulty 
      • T = Time to call 911 
  • Severe pain. A serious pain event is sometimes called a “pain crisis,” “sickle cell crisis,” or “vaso-occlusive crisis.” Many people with sickle cell disease experience this pain, which often requires in-hospital treatment. 

 

  1. National Heart, Lung and Blood Institute. Sickle Cell Disease – Symptoms. www.nhlbi.nih.gov. Published July 14, 2022. https://www.nhlbi.nih.gov/health/sickle-cell-disease/symptoms 
  2. American Stroke Association. Check out the F.A.S.T. Experience. www.stroke.org. https://www.stroke.org/en/fast-experience