The Sickle Cell Information Center is reviewing and revising our Problem-Oriented Clinical Guidelines for adults, children, and adolescents. Check back soon for up-to-date clinical recommendations. In the meantime, please refer to the NIH Evidence Report: Evidence-Based Management of Sickle Cell Disease.
The purpose of the “Evidence-Based Management of Sickle Cell Disease: Expert Panel Report (EPR), 2014” is to synthesize the available scientific evidence on sickle cell disease and offer guidance to busy primary care clinicians. Readers of this report should remember that this document is intended to provide guidance for management, not to be rigidly prescriptive. The panel recognizes that the responsible clinician’s judgment regarding the management of patients remains paramount. Therefore, the Expert Panel Report is a tool to be adopted and implemented in local and individual settings, and to provide an opportunity for shared decisionmaking in which providers and patients are both fully engaged.
NIH Evidence Report: Evidence-Based Management of Sickle Cell Disease (full report)
Table of Contents, Foreword, and Expert Panel
Chapter 1: Introduction and Methodology
Chapter 2: Health Maintenance for People With Sickle Cell Disease
Chapter 3: Managing Acute Complications of Sickle Cell Disease
Chapter 4: Managing Chronic Complications of Sickle Cell Disease
Chapter 5: Hydroxyurea Therapy in the Management of Sickle Cell Disease
Chapter 6: Blood Transfusion in the Management of Sickle Cell Disease
Appendix B: PICOS Questions by Chapter