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Getting older brings big changes for everyone. People with sickle cell disease face these changes too. 

The good news is that people with sickle cell disease are living longer than before.1 In 2008, most people lived to about 50 years old. Now in 2022, most people live to about 60 years old.1,2   

People with sickle cell disease develop all of the complications that individuals without the disease experience. It is very important that they see a primary care doctor to address all of the problems that everyone faces as they age. Some of these problems include:  

  • Diabetes 
  • Cardiovascular Disease 
  • Hypertension 
  • Cancer 
  • Pulmonary Disease 
  • Obesity 

 

How Aging Affects People with Sickle Cell Disease 

People with sickle cell disease start to feel older sooner than other people. The good news is that they have fewer pain crises as they get older.1 They may also look younger than individuals without sickle disease.  

However, older people with sickle cell disease still have pain. The pain is more often chronic and comes from both sickle cell disease and problems everyone face as the age. They might get: 

  • Joint pain from arthritis 
  • Bone and muscle pain 
  • Other aches and pain that come with getting older3 

 

Families and doctors should watch for: 

  • Serious medical problems other than sickle cell causing the pain. 
  • Higher risk of falling 
  • Getting weak or frail at a younger age4 

 

If a person with sickle cell disease also has obesity, hypertension, or diabetes, they may experience more serious health problems from each condition. 

 

Changes in the Body 

As bodies get older, they don’t work as well. This includes making new blood cells. 

Many older people with sickle cell disease get worse anemia. Anemia means you don’t have enough healthy red blood cells. This happens because their bodies can’t make new blood cells as fast.1,5 

 

Kidney Problems 

Kidneys clean waste from your blood. As people get older, kidneys don’t work as well.1 

This is important for people with sickle cell disease. Your doctor might suggest that you: 

  • Treat your blood pressure if it is high 
  • Put you on medicines if you have protein in your urine 
  • Carefully treat your diabetes if you have it 
  • Take a lower dosage of hydroxyurea 
  • Get more regular check-ups to make sure the medicine isn’t hurting causing problems 

Doctors need to watch closely for signs the medicine is causing problems.3,5 

  1. Serjeant GR, Serjeant BE, Mason KP, Hambleton IR, Fisher C, Higgs DR. The changing face of homozygous sickle cell disease: 102 patients over 60 years Int. Jnl. Lab. Hem. 2009, 31, 585–596. 
  2. Bartelt K, Sandberg N, Franklin B, Deckert J. Sickle Cell Patients Are Living a Decade Longer in 2022 Than in 2008. Epic Research. Published online October 5, 2023. https://www.epicresearch.org/articles/sickle-cell-patients-are-living-a-decade-longer-in-2022-than-in-2008 
  3. Platt AF, Eckman J, Hsu LL. Adults Over Sixty-Five. In: Hope and Destiny: The Adult Patient and Parent’s Guide to Sickle Cell Disease and Sickle Cell Trait. 6th ed. Hilton Publishing Company; 2023:101-102.  
  4. Idris IM, Botchwey EA, Hyacinth HI. Sickle cell disease as an accelerated aging syndrome. Exp Biol Med (Maywood). 2022;247(4):368-374. doi:10.1177/15353702211068522  
  5. Oyedeji CI, Hodulik KL, Telen MJ, Strouse JJ. Management of Older Adults with Sickle Cell Disease: Considerations for Current and Emerging Therapies. Drugs Aging. 2023;40(4):317-334. doi:10.1007/s40266-023-01014-8  

Indicators of an Emergency Situation

Patients and families should watch for the following conditions that need an urgent medical evaluation:
• Fever of 101° F or higher
• Chest pain
• Shortness of breath
• Increasing tiredness
• Abdominal swelling
• Unusual headache
• Any sudden weakness or loss of feeling
• Pain that will not go away with home treatment
• Priapism (painful erection that will not go down)
• Sudden vision change

Learn more about sickle cell disease

Getting older brings big changes for everyone. People with sickle cell disease face these changes too. 

The good news is that people with sickle cell disease are living longer than before.1 In 2008, most people lived to about 50 years old. Now in 2022, most people live to about 60 years old.1,2   

People with sickle cell disease develop all of the complications that individuals without the disease experience. It is very important that they see a primary care doctor to address all of the problems that everyone faces as they age. Some of these problems include:  

  • Diabetes 
  • Cardiovascular Disease 
  • Hypertension 
  • Cancer 
  • Pulmonary Disease 
  • Obesity 

 

How Aging Affects People with Sickle Cell Disease 

People with sickle cell disease start to feel older sooner than other people. The good news is that they have fewer pain crises as they get older.1 They may also look younger than individuals without sickle disease.  

However, older people with sickle cell disease still have pain. The pain is more often chronic and comes from both sickle cell disease and problems everyone face as the age. They might get: 

  • Joint pain from arthritis 
  • Bone and muscle pain 
  • Other aches and pain that come with getting older3 

 

Families and doctors should watch for: 

  • Serious medical problems other than sickle cell causing the pain. 
  • Higher risk of falling 
  • Getting weak or frail at a younger age4 

 

If a person with sickle cell disease also has obesity, hypertension, or diabetes, they may experience more serious health problems from each condition. 

 

Changes in the Body 

As bodies get older, they don’t work as well. This includes making new blood cells. 

Many older people with sickle cell disease get worse anemia. Anemia means you don’t have enough healthy red blood cells. This happens because their bodies can’t make new blood cells as fast.1,5 

 

Kidney Problems 

Kidneys clean waste from your blood. As people get older, kidneys don’t work as well.1 

This is important for people with sickle cell disease. Your doctor might suggest that you: 

  • Treat your blood pressure if it is high 
  • Put you on medicines if you have protein in your urine 
  • Carefully treat your diabetes if you have it 
  • Take a lower dosage of hydroxyurea 
  • Get more regular check-ups to make sure the medicine isn’t hurting causing problems 

Doctors need to watch closely for signs the medicine is causing problems.3,5 

  1. Serjeant GR, Serjeant BE, Mason KP, Hambleton IR, Fisher C, Higgs DR. The changing face of homozygous sickle cell disease: 102 patients over 60 years Int. Jnl. Lab. Hem. 2009, 31, 585–596. 
  2. Bartelt K, Sandberg N, Franklin B, Deckert J. Sickle Cell Patients Are Living a Decade Longer in 2022 Than in 2008. Epic Research. Published online October 5, 2023. https://www.epicresearch.org/articles/sickle-cell-patients-are-living-a-decade-longer-in-2022-than-in-2008 
  3. Platt AF, Eckman J, Hsu LL. Adults Over Sixty-Five. In: Hope and Destiny: The Adult Patient and Parent’s Guide to Sickle Cell Disease and Sickle Cell Trait. 6th ed. Hilton Publishing Company; 2023:101-102.  
  4. Idris IM, Botchwey EA, Hyacinth HI. Sickle cell disease as an accelerated aging syndrome. Exp Biol Med (Maywood). 2022;247(4):368-374. doi:10.1177/15353702211068522  
  5. Oyedeji CI, Hodulik KL, Telen MJ, Strouse JJ. Management of Older Adults with Sickle Cell Disease: Considerations for Current and Emerging Therapies. Drugs Aging. 2023;40(4):317-334. doi:10.1007/s40266-023-01014-8  

Indicators of an Emergency Situation

Patients and families should watch for the following conditions that need an urgent medical evaluation:
• Fever of 101° F or higher
• Chest pain
• Shortness of breath
• Increasing tiredness
• Abdominal swelling
• Unusual headache
• Any sudden weakness or loss of feeling
• Pain that will not go away with home treatment
• Priapism (painful erection that will not go down)
• Sudden vision change

Learn more about sickle cell disease

Getting older brings big changes for everyone. People with sickle cell disease face these changes too. 

The good news is that people with sickle cell disease are living longer than before.1 In 2008, most people lived to about 50 years old. Now in 2022, most people live to about 60 years old.1,2   

People with sickle cell disease develop all of the complications that individuals without the disease experience. It is very important that they see a primary care doctor to address all of the problems that everyone faces as they age. Some of these problems include:  

  • Diabetes 
  • Cardiovascular Disease 
  • Hypertension 
  • Cancer 
  • Pulmonary Disease 
  • Obesity 

 

How Aging Affects People with Sickle Cell Disease 

People with sickle cell disease start to feel older sooner than other people. The good news is that they have fewer pain crises as they get older.1 They may also look younger than individuals without sickle disease.  

However, older people with sickle cell disease still have pain. The pain is more often chronic and comes from both sickle cell disease and problems everyone face as the age. They might get: 

  • Joint pain from arthritis 
  • Bone and muscle pain 
  • Other aches and pain that come with getting older3 

 

Families and doctors should watch for: 

  • Serious medical problems other than sickle cell causing the pain. 
  • Higher risk of falling 
  • Getting weak or frail at a younger age4 

 

If a person with sickle cell disease also has obesity, hypertension, or diabetes, they may experience more serious health problems from each condition. 

 

Changes in the Body 

As bodies get older, they don’t work as well. This includes making new blood cells. 

Many older people with sickle cell disease get worse anemia. Anemia means you don’t have enough healthy red blood cells. This happens because their bodies can’t make new blood cells as fast.1,5 

 

Kidney Problems 

Kidneys clean waste from your blood. As people get older, kidneys don’t work as well.1 

This is important for people with sickle cell disease. Your doctor might suggest that you: 

  • Treat your blood pressure if it is high 
  • Put you on medicines if you have protein in your urine 
  • Carefully treat your diabetes if you have it 
  • Take a lower dosage of hydroxyurea 
  • Get more regular check-ups to make sure the medicine isn’t hurting causing problems 

Doctors need to watch closely for signs the medicine is causing problems.3,5 

  1. Serjeant GR, Serjeant BE, Mason KP, Hambleton IR, Fisher C, Higgs DR. The changing face of homozygous sickle cell disease: 102 patients over 60 years Int. Jnl. Lab. Hem. 2009, 31, 585–596. 
  2. Bartelt K, Sandberg N, Franklin B, Deckert J. Sickle Cell Patients Are Living a Decade Longer in 2022 Than in 2008. Epic Research. Published online October 5, 2023. https://www.epicresearch.org/articles/sickle-cell-patients-are-living-a-decade-longer-in-2022-than-in-2008 
  3. Platt AF, Eckman J, Hsu LL. Adults Over Sixty-Five. In: Hope and Destiny: The Adult Patient and Parent’s Guide to Sickle Cell Disease and Sickle Cell Trait. 6th ed. Hilton Publishing Company; 2023:101-102.  
  4. Idris IM, Botchwey EA, Hyacinth HI. Sickle cell disease as an accelerated aging syndrome. Exp Biol Med (Maywood). 2022;247(4):368-374. doi:10.1177/15353702211068522  
  5. Oyedeji CI, Hodulik KL, Telen MJ, Strouse JJ. Management of Older Adults with Sickle Cell Disease: Considerations for Current and Emerging Therapies. Drugs Aging. 2023;40(4):317-334. doi:10.1007/s40266-023-01014-8  

Indicators of an Emergency Situation

Patients and families should watch for the following conditions that need an urgent medical evaluation:
• Fever of 101° F or higher
• Chest pain
• Shortness of breath
• Increasing tiredness
• Abdominal swelling
• Unusual headache
• Any sudden weakness or loss of feeling
• Pain that will not go away with home treatment
• Priapism (painful erection that will not go down)
• Sudden vision change

Learn more about sickle cell disease