This guide will assist programs in developing and establishing a transition program from pediatric to adult care for youth with chronic medical conditions. This manual should be utilized by both pediatric and adult medical providers, hospital systems, and community agencies. The overall purpose of this transition manual is to provide an overview of steps for a successful transition process rather than simply transferring patient care from one setting to another. The hope in producing this manual is to implement a transition process that encourages empowerment, advocacy skills, and communication abilities; thus, leading to decreased morbidity and mortality rates in young adults with chronic illnesses post-transition.